A 83-01 (50 mg)- 信号转导- 激动剂抑制剂-优宁维生化试剂平台
A 83-01 (50 mg)
货号: 2939/50 品牌: Tocris 分子式:
C25H19N5S
C25H19N5S
规格: 50mg
产品说明书
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价格: ¥ 13320.00

数量
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概述
别名
3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
是否允许进口
允许
是否危险品
非危险品
性能
供应商
Tocris
生物活性
Potent inhibitor of TGF-β type I receptor ALK5 kinase, type I activin/nodal receptor ALK4 and type I nodal receptor ALK7 (IC50 values are 12, 45 and 7.5 nM respectively). Blocks phosphorylation of Smad2 and inhibits TGF-β-induced epithelial-to-mesenchymal transition. Only weakly inhibits ALK-1, -2, -3, -6 and MAPK activity. More potent than SB 431542 (Cat.No. 1614). Inhibits differentiation of rat induced pluripotent stem cells (riPSCs) and increases clonal expansion efficiency. Helps maintain homogeneity and long-term in vitro self-renewal of human iPSCs.
存放说明
Frost Free Freezer -20 degrees C
纯度
>98 %
计算分子量
421.52
分子式
C25H19N5S
可溶性/溶解性
Soluble to 50 mM in DMSO
CAS号
909910-43-6
参考文献

Li et al (2009) Generation of rat and human induced pluripotent stem cells by combining genetic reprogramming and chemical inhibitors. Cell Stem Cell 4 16. PMID: 19097958.

Hoberg et al (2008) Attachment to laminin-111 facilitates transforming growth factor β-induced expression of matrix metalloproteinase-2 in synovial fibroblasts. Ann.Rheum.Dis. 66 446.

Tojo et al (2005) The ALK5 inhibitor A-83-01 inhibits smad signaling and epithelial-to-mesenchymal transition by transforming growth factor-β. Cancer.Sci. 96 791. PMID: 16271073.

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